英国《泰晤士报》日前报道说,最新的研究显示,一种从红辣椒中提取的新型止痛药可能妨碍学习和记忆等脑功能。
制药公司一直在试验这种利用红辣椒中的烈性化合物辣椒素的暂时镇痛作用研制的药物。研制该药物的目的只是为了抑制向大脑发送疼痛信号的神经,但老鼠试验表明,这种镇痛
作用可能会导致连锁反应。
美国研究人员在《神经元》杂志上发表文章说,该药物会作用于一个叫做TRPVI的大脑感受器,TRPVI既控制痛感,还主要控制着情绪和记忆的过程。该发现可能也有助于解释减肥药Acom plia潜在的自杀性副作用。
生物谷推荐原始出处:
Neuron, Vol 57, 629-631, 13 March 2008
Hotheaded: TRPV1 as Mediator of Hippocampal Synaptic Plasticity
Benedict J. Alter1 and Robert W. Gereau IV1,
1 Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Summary
TRPV1 is a sensory transduction channel that mediates thermal nociception and some aspects of pathological pain. In this issue of Neuron, Gibson et al. report that TRPV1 also plays important roles in hippocampal synaptic plasticity, presenting a potential challenge for TRPV1-targeted therapeutics for the treatment of pain.